Bioactive Metabolites from the Caribbean Sponge Aka coralliphagum

Grube, Achim, Assmann, Michael, Lichte, Ellen, Sasse, Florenz, Pawlik, Joseph R and Köck, Matthias ;

Contact

Matthias.Koeck [ at ] awi.de

Abstract

The chemistry of the burrowing sponge Aka coralliphagum was investigated to identify chemically labile secondary metabolites. The HPLC-MS analysis of the two growth forms typica and incrustans revealed different metabolites. The previously unknown sulfated compounds siphonodictyals B1 to B3 (6-8), corallidictyals C (9) and D (10), and siphonodictyal G (11) were isolated, and their structures were elucidated by NMR and MS experiments. The compounds were tested in a DPPH assay, in antimicrobial assays against bacteria, yeasts, and fungi, and in antiproliferation assays using cultures of mouse fibroblasts. The biological activity was linked to the presence of the ortho-hydroquinone moiety.

Item Type

Article

Authors

Grube, Achim, Assmann, Michael, Lichte, Ellen, Sasse, Florenz, Pawlik, Joseph R and Köck, Matthias ;

Divisions

AWI Organizations > Biosciences > Ecological Chemistry

Programs

Helmholtz Research Programs > MARCOPOLI (2004-2008) > CO-MARCOPOLI
Helmholtz Research Programs > MARCOPOLI (2004-2008) > CO3-Chemical Interactions - ecological function and effects

Publication Status

Published

Eprint ID

16085

DOI https://www.doi.org/10.1021/np0603018

Cite as

Grube, A. , Assmann, M. , Lichte, E. , Sasse, F. , Pawlik, J. R. and Köck, M. (2007): Bioactive Metabolites from the Caribbean Sponge Aka coralliphagum , Journal of Natural Products, 70 (4), pp. 504-509 . doi: https://www.doi.org/10.1021/np0603018

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