Seismic velocities and the associated thicknesses of rifted and igneous crust provide key constraints on the rifting history, the differentiation between non-volcanic and volcanic rifted margins, the driving force of magmatism at volcanic margins, that is, active or passive upwelling and the temperature anomaly in the lithosphere. This paper presents two new wide-angle seismic transects of the East Greenland margin and combines the velocity models with a compilation of 30-wide-angle seismic velocity models from several publications along the entire East Greenland margin. Compiled maps show the depth to basement, depth to Moho, crustal thickness and thickness of high velocity lower crust (HVLC; with velocities above 7.0 km s-1). First, we present two new wide-angle seismic transects, which contribute to the compilation at the northeast Greenland margin and over the oceanic crust between Shannon Island and the Greenland Fracture Zone. Velocity models, produced by ray tracing result in total traveltime rms-misfits of 100-120 milliseconds and χ2 values of 3.7 and 2.3 for the northern and southern profiles with respect to the data quality and structural complexity. 2-D gravity modelling is used to verify the structural and lithologic constraints. The northernmost profile, AWI-20030200, reveals a magma starved break-up and a rapidly thinning oceanic crust until magnetic anomaly C21 (47.1 Ma). The southern seismic transect, AWI-20030300, exhibits a positive velocity anomaly associated with the Shannon High, and a basin of up to 15 km depth beneath flood basalts between Shannon Island and the continent-ocean boundary. Break-up is associated with minor crustal thickening and a rapidly decreasing thickness of oceanic crust out to anomaly C21. The continental region is proposed to be only sparsely penetrated by volcanism and not underplated by magmatic material at all compared to the vast amount of magmatism further south. Break-up is proposed to have occurred at the seaward boundaries of the continent-ocean transition zones at between ∼50 and ∼54 Ma, propagating from north to south based on a joint analysis incorporating transects from the Kejser Franz Joseph Fjord and Godthåb Gulf. Secondly, the variation of the HVLC along the East Greenland margin from 60° to 77°N and from transects of its conjugate margin shows inverted emplacement of prominent landward and seaward HVLC thickness portions from north to south in a distribution chart. The differences in the HVLC distribution are attributed to one or more of the following three models. In the first model it is inferred that a transfer zone/detachment acts as a barrier to northward magma flow. In the second model, underplating results in thicker and highly intruded lower crust with several small-scale feeder dykes that locally increase the lower crustal velocities. In the third model, a second magmatic event associated with the separation of the Jan Mayen microcontinent is considered. Lithospheric-scale inhomogeneities might be responsible for the heterogeneous melt generation, the inversion of the HVLC distribution in continental and oceanic domains and differences in its velocities. © 2009 The Authors Journal compilation © 2009 RAS.