The ANDRILL Program successfully recovered a 1285 m-long succession of cyclic glacimarine sediment with interbedded volcanic deposits in its first season of drilling from the McMurdo Ice Shelf (MIS). The MIS AND-1B drill core represents the longest and most complete (98% recovery) geological record from the Antarctic continental margin to date, and will provide a key reference record of climate and ice-sheet variability through the Late Cenozoic. Here we present a synopsis of this Initial Science Report with emphasis on the potential of the record for improving our knowledge of Antarctica's influence on global climate.