Stylissamides E and F, Cyclic Heptapeptides from the Caribbean Sponge Stylissa caribica

Cychon, Christine and Köck, Matthias ;

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Matthias.Koeck [ at ] awi.de

Abstract

In addition to the four known stylissamides, A (1), B (2), C, and D, two new cyclic heptapeptides, stylissamides E (3) and F (4), were isolated from the Caribbean sponge Stylissa caribica. The structures of 3 and 4 were elucidated from a combination of mass spectrometric and NMR spectroscopic data as cyclo-(cis-Pro(1)-Tyr(2)-trans-Pro(3)-Ala(4)-Ile(5)-Gln(6)-Ile(7)) for stylissamide E (3) and cyclo-(trans-Pro(1)-cis-Pro(2)-Phe(3)-Asp(4)-trans-Pro(5)-Arg(6)-Phe(7)) for stylissamide F (4).

Item Type

Article

Authors

Cychon, Christine and Köck, Matthias ;

Divisions

AWI Organizations > Biosciences > Ecological Chemistry

Programs

Helmholtz Research Programs > PACES I (2009-2013) > TOPIC 2: Coastal Change
Helmholtz Research Programs > PACES I (2009-2013) > TOPIC 2: Coastal Change > WP 2.2: Integrating evolutionary Ecology into Coastal and Shelf Processes

Publication Status

Published

Eprint ID

23084

DOI https://www.doi.org/10.1021/np900664f

Cite as

Cychon, C. and Köck, M. (2010): Stylissamides E and F, Cyclic Heptapeptides from the Caribbean Sponge Stylissa caribica , Journal of Natural Products, 73 (4), pp. 738-742 . doi: https://www.doi.org/10.1021/np900664f

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