Perspectives on the synthesis and use of ageladine A

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Contact

Ulf.Bickmeyer [ at ] awi.de

Abstract

Focusing on the marine-derived alkaloid ageladine A ([4-(4,5-dibromo-1H-pyrrol-2-yl)]-1H-imidazo[4, 5-c]pyridin-2-amine trifluoroacetate), we combined and modified published strategies to develop a synthesis method with easily managed reaction steps that allows gram-scale batch synthesis. On exploration additional features of the fluorescent properties of the compound were revealed. In tissues and cells of a marine flatworm, the emission profile shifted to longer wavelengths than in water. The fluorescence emission maximum shifted around 30–450 nm and the profile showed sufficient intensity at approximately 550 nm and above

Item Type

Article

Authors

Mordhorst, Thorsten and Bickmeyer, Ulf

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Divisions

AWI Organizations > Biosciences > Ecological Chemistry

Primary Division

Organizations > AWI Organizations > Biosciences > Ecological Chemistry

Programs

Helmholtz Research Programs > PACES II (2014-2020) > TOPIC 2: Fragile coasts and shelf sea > WP 2.3: Evolution and adaptation to climate change and anthropogenic stress in coastal and shelf systems

Primary Topic

Helmholtz Programs > Helmholtz Research Programs > PACES II (2014-2020) > TOPIC 2: Fragile coasts and shelf sea > WP 2.3: Evolution and adaptation to climate change and anthropogenic stress in coastal and shelf systems

Publication Status

Published

Eprint ID

38234

DOI 10.1016/j.tetlet.2015.05

Cite as

Mordhorst, T. and Bickmeyer, U. (2015): Perspectives on the synthesis and use of ageladine A , Tetrahedron Letters, 56 , pp. 4363-4366 . doi: 10.1016/j.tetlet.2015.05

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