The Antarctic Peninsula has exhibited some of the most spectacular changes observed in glacial systems in recent decades. The events include disintegration of ice shelves, acceleration and thinning of glaciers, variations in the limits between glacier facies, and retreat of glacier fronts. However, due to the lack of both consistent systematic observations of the glacial systems and information on their boundary conditions, it is difficult to accurately predict the contribution of Antarctic Peninsula glaciers to sea level rise and further responses of these ice masses to climatic and oceanographic changes. In this context, the activities of the GLIMS Regional Center for the Antarctic Peninsula and its network of international collaborators are based on the use of various types of Earth observation imagery, mainly optical and radar data. Although a complete glacier inventory is still lacking, we present the results of changes in glacier frontal positions and boundaries of glacier facies as well as links to dynamical adjustments for various locations in the Antarctic Peninsula’s ice masses. Evaluation of Advanced Spaceborne Thermal Emission and reflection Radiometer (ASTER) digital elevation models generated for the Antarctic Peninsula is also discussed.