<jats:title>Abstract</jats:title> <jats:p>Five years of continuous mooring data combined with conductivity–temperature–depth (CTD)/lowered acoustic Doppler current profiler (LADCP) measurements from five cruises are used to investigate the influence of the deep western boundary current (DWBC) on the internal wave field and associated vertical mixing at the continental slope at 16°N in the western Atlantic. The mooring data include 2-hourly rotor current-meter measurements and temperature/conductivity time series with a high temporal resolution of 5–20 min. Thus, the data resolve time scales ranging from the low-frequency variability of the large-scale DWBC that generates internal waves due to interactions with the topography to frequencies greater than that of internal waves that are associated with vertical mixing. Estimates of the vertical mixing induced by the breaking of the observed internal waves show elevated diapycnal diffusivities of up to 10−3 ± 0.4 × 10−3 m2 s−1 in the bottommost 1500 m during times of a strong DWBC (maximum velocities at the mooring site up to 50 cm s−1) whereas vertical mixing rates are about an order of magnitude lower (1.6 × 10−4 ± 0.6 × 10−4 m2 s−1) during weak flow. During periods of a strong DWBC, spectra of horizontal velocity and internal wave available potential energy change substantially at depths below 1200 m and show a strong increase in variance particularly in the near-inertial frequency band. Low-frequency, near-inertial waves generated by topography/DWBC interaction on the slope to the west of the moorings can potentially cause this observed wave intensification; ray paths estimated for these waves agree well with the observed spectral changes at different depths. Variability in the high-frequency range, considered as a proxy for turbulent mixing, is significantly correlated with the DWBC strength above the continental slope.</jats:p>