hdl:10013/epic.14870
Synthesis of the marine natural product N-alpha-(4-bromopyrrolyl-2-carbonyl)-L-homoarginine, a putative biogenetic precursor of the pyrrole-imidazole alkaloids
Lindel, T., Hochgürtel, M., Assmann, M. and Köck, Matthias ORCID: https://orcid.org/0000-0003-0211-6341
;
Contact
massmann [ at ] awi-bremerhaven.de
Abstract
Lysine is proposed as an alternative biosynthetic precursor of the pyrrole-imidazole alkaloids frequently found in marine sponges. As a putative key intermediate, the natural product N-alpha-(4-bromopyrrolyl-2-carbonyl)-L-homoarginine (1) from the sponge Agelas wiedenmayeri was synthesized in the solid phase starting from the Fmoc/Pmc-protected L-homoarginine and in solution starting from readily available L-lysine methyl ester.
Item Type
Article
Authors
Lindel, T., Hochgürtel, M., Assmann, M. and Köck, Matthias ORCID: https://orcid.org/0000-0003-0211-6341
;
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ISI/Scopus peer-reviewed
Publication Status
Published
Eprint ID
4295
Cite as
Lindel, T.
,
Hochgürtel, M.
,
Assmann, M.
and
Köck, M.
(2000):
Synthesis of the marine natural product N-alpha-(4-bromopyrrolyl-2-carbonyl)-L-homoarginine, a putative biogenetic precursor of the pyrrole-imidazole alkaloids
,
Journal of Natural Products,
63
,
pp. 1566-1569
.
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