hdl:10013/epic.49913
publisher:10.1021/acs.jnatprod.5b00265
Hybrid Pyrrole–Imidazole Alkaloids from the Sponge Agelas sceptrum1
Muñoz, Julie and Köck, Matthias
;
Contact
Matthias.Koeck [ at ] awi.de
Abstract
A chemical investigation of the tropical sponge Agelas sceptrum from Plana Cays (Bahamas) led to the isolation of two hybrid pyrrole-imidazole alkaloids (PIAs), 15'-oxoadenosceptrin (1) and decarboxyagelamadin C (2). Herein, we report their challenging structure elucidation established by NMR and ECD spectroscopy. 15'-Oxoadenosceptrin (1) shows sceptrin merged with an adenine moiety, not yet encountered in the PIA family, whereas decarboxyagelamadin C (2) is a close derivative of agelamadins C to E recently isolated from an Agelas sp. from Okinawa.
Item Type
Article
Authors
Muñoz, Julie and Köck, Matthias
;
Divisions
Primary Division
Programs
Helmholtz Research Programs > PACES II (2014-2020) > TOPIC 2: Fragile coasts and shelf sea > WP 2.3: Evolution and adaptation to climate change and anthropogenic stress in coastal and shelf systems
Primary Topic
Helmholtz Programs > Helmholtz Research Programs > PACES II (2014-2020) > TOPIC 2: Fragile coasts and shelf sea
Publication Status
Published
Eprint ID
43235
DOI
https://www.doi.org/10.1021/acs.jnatprod.5b00265
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Cite as
Muñoz, J.
and
Köck, M.
(2016):
Hybrid Pyrrole–Imidazole Alkaloids from the Sponge Agelas sceptrum1
,
Journal of Natural Products,
79
(2),
pp. 434-437
.
doi: https://www.doi.org/10.1021/acs.jnatprod.5b00265
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