Overview The Indian Ocean remains one of the most poorly sampled and overlooked regions of the world ocean. Today, more than 25% of the world’s population lives in the Indian Ocean region and the population of most Indian Ocean rim nations is increasing rapidly. These increases in population are giving rise to mul- tiple stressors in both coastal and open ocean environments. Combined with warming and acidification due to global climate change, these regional stressors are resulting in loss of biodi- versity in the Indian Ocean and also changes in the phenology and biogeography of many spe- cies. These pressures have given rise to an urgent need to understand and predict changes in the Indian Ocean, but the measurements that are needed to do this are still lacking. In response, SCOR, IOC, and IOGOOS have stimulated a second International Indian Ocean Expedition (IIOE-2). An international Science Plan and an Implementation Strategy for IIOE-2 have been developed, the formulation of national plans is well underway in several countries, and new research initiatives are being motivated. An Early-Career Scientist Network for Indian Ocean Research has self-organized to support the Expedition. The success of IIOE-2 will be gauged not just by how much it advances our understanding of the complex and dynamic Indian Ocean system, but also by how it con- tributes to sustainable development of marine resources, environmental stewardship, ocean and climate forecasting, and training of the next generation of ocean scientists. We encourage ASLO members to get involved.