A Coralline Algal-Associated Bacterium, Pseudoalteromonas Strain J010, Yields Five New Korormicins and a Bromopyrrole


Contact
tilmann.harder [ at ] awi.de

Abstract

The ethanol extract of Pseudoalteromonas strain J010, isolated from the surface of the crustose coralline alga Neogoniolithon fosliei, yielded thirteen natural products. These included a new bromopyrrole, 4′-((3,4,5-tribromo- 1H-pyrrol-2-yl)methyl)phenol (1) and five new korormicins G-K (2-6). Also isolated was the known inducer of coral larval metamorphosis, tetrabromopyrrole (TBP), five known korormicins (A-E, previously named 1, 1a-c and 3) and bromoalterochromide A (BAC-A). Structures of the new compounds were elucidated through interpretation of spectra obtained after extensive NMR and MS investigations and comparison with literature values. The antibacterial, antifungal and antiprotozoal potential of 1-6, TBP and BAC-A was assessed. Compounds 1-6 showed antibacterial activity while BAC-A exhibited antiprotozoal properties against Tetrahymena pyriformis. TBP was found to have broad-spectrum activity against all bacteria, the protozoan and the fungus Candida albicans. © 2014 by the authors licensee MDPI.



Item Type
Article
Authors
Divisions
Primary Division
Programs
Primary Topic
Publication Status
Published
Eprint ID
46344
DOI https://www.doi.org/10.3390/md12052802

Cite as
Tebben, J. , Motti, C. , Tapiolas, D. , Thomas-Hall, P. and Harder, T. (2014): A Coralline Algal-Associated Bacterium, Pseudoalteromonas Strain J010, Yields Five New Korormicins and a Bromopyrrole , Marine Drugs, 12 (5), pp. 2802-2815 . doi: https://www.doi.org/10.3390/md12052802


Share


Citation

Geographical region

Research Platforms
N/A

Campaigns
N/A


Actions
Edit Item Edit Item