This is the first study presents the patterns and environmental controls of benthic biomass size spectra, carbon demand, and production along the entire bathymetric gradient from the shelf to the abyssal depths in the transition zone between the northern North-Atlantic and the central Arctic Ocean. The material was collected at 17 stations (76-5561 m) in the eastern Fram Strait, in the vicinity of the productive Marginal Ice Zone, with increased food availability from phytodetritus sedimentation compared to other deep-sea localities at similar depths. Meiobenthic and macrobenthic individuals were measured using image analysis to assess their biovolume, biomass, annual production, and carbon demand. Benthic biomass in the study area was clearly higher than that in High Arctic locations and comparable to that in the lower-latitude North Atlantic. Biomass and annual production were significantly negatively correlated with water depth, with stronger bathymetric clines in macrofauna than in meiofauna and the increasing dominance of meiofauna with increasing depth. The entire range of the spectra (i.e., the number of size classes) decreased with increasing depth, especially in the macrofaunal part of the spectrum. Similar slope values in the normalized spectra indicated that the distribution of the biomass across the present size classes was consistent from the shelf to the abyssal depths, irrespective of the decreasing amount of food availability. The fragmented macrofaunal size spectra documented at two specific stations were probably due to physical disturbances at the sediment-water interface (e.g., intense bioturbation of holothurians and strong near-bottom currents). Benthic carbon demand declined from 50.7 gC m−2 y−1 at the shelf to 11.5 gC m−2 y−1 at the slope to 2.2 gC m−2 y−1 at the abyssal depths, and its partitioning among meiofauna and macrofauna changed with water depth, with meiofauna contributions increasing from 50% at the shelf to over 90% at the deepest station. The estimated total benthic carbon demand exceeded the vertical Corg fluxes, suggesting that the studied system can be particularly sensitive to future changes in productivity regimes and associated organic matter fluxes.