Water masses and depositional environments over the last 500 ka were reconstructed using absolute and relative abundances of lithogenous, biogenous and redox-sensitive elements in four sediment cores from two channel-levee systems of the Wilkes Land continental slope (East Antarctica). Sediments older than the Mid-Bruhnes event (MBE, 430 ka BP) show reduced glacial/interglacial variability in the abundance of elements associated to the terrigenous mineral phases (i.e. Al, Ti, Fe and partly Si). This suggests minor ice-sheet size changes occurred in the Antarctic margin during the pre-MBE “lukewarm” interval. Post-MBE sediments record instead a high variability between glacial and interglacial periods in the concentration of terrigenous and biogenous (i.e. Ca, Ba) elements suggesting larger amplitude changes in both ice-sheet size and ocean conditions toward the gradual establishment of last glacial cycle conditions. Moreover, a marked increase of Mn during the glacial to interglacial transitions, indicates a post-depositional migration of the redox front and re-oxidation of the surface sediment layers linked to major changes in bottom water oxygen conditions associated to Antarctic Bottom Water formation along the margin at the onset of deglaciations.