Marine microbial communities produce a high diversity of natural products encoded by Biosynthetic Gene Clusters (BGCs). So far most of this metabolic diversity remains unknown, due to technical limitations in studying microorganisms. Metagenomics represents a powerful approach to access the metabolic potential of microbial communities. In this work, we used the metagenomic data from the TARA Oceans and Ocean Sampling Day sequencing campaigns, in order to study the biogeography of BGCs in marine environments. These datasets offer a valuable opportunity to explore the unknown world of BGCs of marine microbial communities, and the underlying mechanisms that structure the composition of these genes in the environment. It represents the first biogeographic analysis of BGCs on marine environments on a global scale.