The relationship between River Ammer flood frequency variability, extreme summer climate over Europe, and solar forcing is investigated. First, we used observational data to evaluate extreme weather and climate anomaly patterns associated with flood and solar forcing as well as the possible dynamical mechanisms behind them. Then, the annual resolution flood layer record from the Lake Ammer sediments is analysed to evaluate millennial-scale variability of floods and possible related extreme climate patterns back to 5,500 years BP. A composite analysis reveals that observed River Ammer flood frequency variability at interannual to multidecadal time scales is connected to large-scale extreme precipitation and temperature patterns. From a synoptic-scale perspective, the extreme precipitation pattern associated with floods is related to an increase in the frequency of high upper-level potential vorticity (PV) events over western Europe and a decrease over eastern Europe and western Russia. Increased (decreased) frequency of upper-level high PV events is related to more (less) surface extreme precipitation occurrence. Furthermore, we show that increased frequency of upper-level high PV events over western Europe is associated with enhanced blocking activity over eastern Europe. Therefore, the out of phase interannual to millennial-scale variations of River Ammer flood frequency and solar irradiance, as presented in previous studies, can be explained by a solar modulation of eastern European-western Russia summer blocking and associated upstream upper-level wave breaking activity. In addition, we identify two distinct quasi-periodic signals in both frequency of Lake Ammer flood layer and solar irradiance records with periods of ~900 years and ~2,300 years. We argue that similar cycles should dominate millennial-scale variations of blocking activity in eastern Europe-western Russia as well as extreme precipitation and flood frequency variability over central and western Europe during the last ~5,500 years.