Until recently, little was known about the Quaternary marine sedimentary record in East Greenland. Geophysical and geological investigations in Scoresby Sund were undertaken to characterize the nature and chronology of this record. Seismic records show that almost 70% of the outer fjord system is covered by about 10 m of unlithified sediments, making direct correlation with the Quaternary records on land and the adjacent continental margin difficult. These acoustically unstratified sediments are scoured by icebergs above 550 m water depth. Almost 90% of core material is massive diamicton of Holocene age, deposited mainly from iceberg rafting and turbid meltwater. Sedimentation rates are 0.1 ‐0.3 m 1000 yr‐1. Thicker accumulations of unlithified Quaternary sediments in Scoresby Sund occur as sediment ridges and in two other major depocentres. A low sediment ridge runs across the mouth of Scoresby Sund, and is interpreted as an end moraine of Late Weichselian Flakkerhuk stadial age. The very restricted sediment thickness suggests that grounded ice filled the fjord during the Flakkerhuk and an ice shelf was not present. High inputs of ice rafted debris to the continental margin at about 18 000 BP indicate this as a probable age for the moraine. During the Allerød Interstadial, ice probably retreated from the outer fjord system, since massive diamictons similar to those of Holocene age are present at the base of most cores. A major depocentre of acoustically stratified sediments at the head of Hall Bredning is interpreted to represent ice proximal deposits from a glacier margin extending across the fjord. It is adjacent to dated moraines on land and is inferred to be of Milne Land stadial age (about 10 000 BP). A similar age is interpreted for acoustically laminated sediments and a moraine at the entrance of Vikingebugt, on the south side of Scoresby Sund. Dated kame terraces in the inner fjord system indicate that ice retreated to its present position 6–7000 years ago. Copyright © 1994, Wiley Blackwell. All rights reserved