Tetrandrine effects on calcium currents in cultured neurones of foetal mice

Bickmeyer, Ulf and Wiegand, Herbert ;

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ubickmeyer [ at ] awi-bremerhaven.de

Abstract

Tetrandrine, a bis-benzyl-isoquinoline alkaloid from the roots of Stefania Tetranda blocks calcium currents in cultured neurones of the spinal cord of foetal mice. The concentration of half-maximal effect (Kd) measured 100 ms after the beginning of a depolarizing pulse (-80 mV-0 mV) is 8 microM. While high- and low-voltage activated (HVA, LVA) currents are both blocked by Tetrandrine, the slowly inactivating HVA currents appear to be a primary target.

Item Type

Article

Authors

Bickmeyer, Ulf and Wiegand, Herbert ;

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Non-AWI items

Programs

Basic Research > Helmholtz Independent Research

Publication Status

Published

Eprint ID

7185

DOI https://www.doi.org/10.1097/00001756-199307000-00025

Cite as

Bickmeyer, U. and Wiegand, H. (1993): Tetrandrine effects on calcium currents in cultured neurones of foetal mice , NeuroReport, 4 (7), pp. 938-940 . doi: https://www.doi.org/10.1097/00001756-199307000-00025

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