New Communesin Derivatives from the Fungus Penicillium sp. Derived from the Mediterranean Sponge Axinella verrucosa

hdl:10013/epic.20442

New Communesin Derivatives from the Fungus Penicillium sp. Derived from the Mediterranean Sponge Axinella verrucosa

Jadulco, Raquel, Edrada, Ru Angelie, Ebel, Rainer, Berg, Albrecht, Schaumann, Karsten, Wray, Victor, Steube, Klaus and Proksch, Peter ;

Contact

kschaumann [ at ] awi-bremerhaven.de

Abstract

The ethyl acetate extract of Penicillium sp., derived from the Mediterranean sponge Axinella verrucosa, yielded the known compound communesin B (1) and its new congeners communesins C (2) and D (3), as well as the known compounds griseofulvin, dechlorogriseofulvin, and oxaline. All structures were unambiguously established by 1D and 2D NMR and MS data. In several bioassays performed on different leukemia cell lines, the communesins exhibited moderate antiproliferative activity.

Item Type

Article

Authors

Jadulco, Raquel, Edrada, Ru Angelie, Ebel, Rainer, Berg, Albrecht, Schaumann, Karsten, Wray, Victor, Steube, Klaus and Proksch, Peter ;

Divisions

AWI Organizations > Biosciences > Ecological Chemistry

Programs

Basic Research > Helmholtz Independent Research

Publication Status

Published

Eprint ID

9947

DOI https://www.doi.org/10.1021/np030271y

Cite as

Jadulco, R. , Edrada, R. A. , Ebel, R. , Berg, A. , Schaumann, K. , Wray, V. , Steube, K. and Proksch, P. (2003): New Communesin Derivatives from the Fungus Penicillium sp. Derived from the Mediterranean Sponge Axinella verrucosa , Journal of Natural Products, 67 (1), pp. 78-81 . doi: https://www.doi.org/10.1021/np030271y

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